The main focus of the study was on individual combined oral contraceptives, which included all the most commonly used preparations in the UK: norethisterone, levonorgestrel, norgestimate, desogestrel, gestodene, and drospirenone (BNF 7.3.1). We included cyproterone, a hormonal treatment for acne, because it is also used as an oral contraceptive owing to its progestogen like effect on the release of testosterone by the ovaries (BNF 13.6.2). For confounder control, the analysis included oral progestogen only contraceptives (BNF 7.3.2) and non oral hormonal contraceptives (BNF 7.3.1 and BNF 7.3.2: implants, injections, transdermal patches, intrauterine and vaginal devices).We investigated the recency of use by calculating the gap in days between the estimated date for the last use of a combined oral contraceptive and the index date, and categorising it as follows: used at index date or last use 1 28 days before the index date (current use); last use 29 365 days before the index date (past use); or no use in the last year before the index date.
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